Last year, former Harvard president Lawrence Summers caused quite a stir with his comment that innate differences between the genders might explain the number disparity we see.
Here is an interesting article in the Washington Post that follows up a commentary in Nature by scientist Ben Barres (who used to be Barbara Barres).
Aside from the article being interesting, there is the following highly amusing anecdote:
After he underwent a sex change nine years ago at the age of 42, Barres recalled, another scientist who was unaware of it was heard to say, "Ben Barres gave a great seminar today, but then his work is much better than his sister's."
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